Acute Stroke
Stroke Recovery
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Traumatic Brain Injury
Spinal Cord Injury
Muscular Dystrophy
Myocardial Infarction
Peripheral Vascular Disease
Others
Will Travel Services

Preclinical Animal Models & CRO Services

Services: In-House Models | Will Travel Services

Animal Models:

Biotrofix offers special expertise in rodent models of neurological and vascular diseases, including:

•	Acute Stroke-mouse and rat models of acute focal cerebral ischemia, suitable for testing of neuroprotective treatments
•	Stroke Recovery-rat models of focal cerebral ischemia compatible with prolonged animal survival, suitable for testing of recovery-promoting treatments
•	Alzheimer's Disease (AD)-transgenic mouse models of amyloid deposition and neuronal loss, suitable for testing of AD treatments
•	Amyotrophic Lateral Sclerosis (ALS)-transgenic mouse models of mutant SOD-1 expression, suitable for testing of ALS treatments
•	Traumatic Brain Injury (TBI)-rat models of TBI, suitable for testing of neuroprotective or recovery-promoting strategies
•	Spinal Cord Injury (SCI)-mouse and rat models of SCI, suitable for testing of neuroprotective or recovery-promoting strategies.
•	Muscular Dystrophy
•	Myocardial Infarction
•	Peripheral Vascular Disease
•	Other Diseases: mouse and rat models of muscular dystrophy, diabetes, peripheral vascular disease, and others under development
•	Will Travel Services: Biotrofix personnel will travel to other companies

Preclinical CRO Services, Animal Models, Drug Administration, Behavioral Assessment, Tissue Sampling and Histology

Drug Administration:

Delivery of small molecules, proteins, cells, or appropriate devices in the models above via intracerebral, intrathecal, systemic, oral, or local administration, either by injection or continuous infusion. Single, multiple, or continuous dosing.

Behavioral Assessment:

Biotrofix investigators are highly-experienced in behavioral assessment in rodent models of neurological and vascular diseases. These include assessment of:

Sensorimotor Function: limb placing tests, tail swing test, neurological severity scale, beam balance, spontaneous limb use, grid walking, staircase, sticky tape, paw reaching, rotorod, and rotating beam tests.
Memory: novel object recognition, Morris water maze test, contextual fear conditioning.
Other model-specific behavioral tests are also available.

Tissue Sampling and Histology:

•	Blood, urine, and CSF sampling for PK and PD studies.
•	Brain and other organ harvesting, fixation, sectioning, and routine histological processing.
•	Infarct volume analysis for stroke studies.
•	Immunocytochemistry studies are done through special arrangement.

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Biotrofix is a premier preclinical contract research organization specializing in animal models of CNS, cardiac and vascular disease. With years of experience, both academic, commercial, clients throughout the biotech and pharmaceutical industries, Biotrofix delivers industry-leading preclinical CRO services, including rodent models of acute stroke and stroke recovery, preclinical CRO services for Alzheimer's Disease, transgenic animal models for ALS, as well as CRO services for brain injury, preclinical CRO services for spinal cord injury and related cardiac drug discovery and development.