Peripheral Vascular Disease Animal Models & CRO Services

Peripheral Vascular Disease Animal Models & CRO Services - Preclinical Drug Development, Cardiac Disease - Blockage of peripheral arteries. Peripheral vascular disease (PVD) refers to blockage of peripheral arteries supplying the lower extremities, resulting in leg pain and cramping with walking. PVD arises from the process of atherosclerosis that is also the general cause of myocardial infarction (MI, “heart attack”) and stroke. Biotrofix is experienced in rodent models of PVD, esp. unilateral ligation of the femoral artery in rats and mice. Endpoints of these studies include blood flow (laser Doppler flowmetry) and functional status in ischemic limbs.

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Biotrofix is a premier preclinical contract research organization specializing in animal models of CNS, cardiac and vascular disease. With years of experience, both academic, commercial, clients throughout the biotech and pharmaceutical industries, Biotrofix delivers industry-leading preclinical CRO services, including rodent models of acute stroke and stroke recovery, preclinical CRO services for Alzheimer's Disease, transgenic animal models for ALS, as well as CRO services for brain injury, preclinical CRO services for spinal cord injury and related cardiac drug discovery and development.