Acute Stroke Animal Models & CRO Services
Stroke is the third leading cause of death and disability in the U.S., with approximate 800,000 new cases per year. Eighty-five percent of strokes are "ischemic," due to occlusion of a brain artery, causing death of brain tissue (infarction) supplied by that artery.
Acute stroke treatments are given within a few hours after stroke onset. Such treatments include thrombolytic ("clot-busting") and tissue-sparing ("neuroprotective") agents. Biotrofix is highly experienced in rodent (mouse and rat) models of acute focal stroke, including suture-occlusion, Chen, Tamura, and embolic methods. These models are suitable for testing of new thrombolytic and neuroprotective strategies. Endpoints of these studies include histology (infarct volume determination) and behavioral testing.
Download ACUTE STROKE NEUROPROTECTION MODEL (.pdf)